VP-DSC MicroCal/Malvern Microcalorimeter
Contact: Roman Szczepanowski
Access to the instrument after short training
Differential Scanning Calorimetry (DSC) is a powerful analytical technique for characterizing the thermal stability of the biological macromolecules.
DSC directly measures heat changes that occur in the sample solution during a precise increase or decrease of the temperature, analyzing a temperature difference between the sample and the reference cells.
By measuring the change of heat capacity (ΔCp) as a function of temperature, DSC allows the direct determination of the variations of enthalpy (ΔH), entropy (ΔS), and the mid-transition temperature (Tm, when 50% of the molecules are in unfolded state), associated to each structural transition.
Operating Temperature Range: -10° to 130°C
Cell Design: Tantalum, coin shape, 0.5 ml. For safe loading min. 1.2 ml of solution is necessary.
Up-scans speed: 0°C/hr to 90°C/hr, down-scans: scan rates: 0°C/hr to -60°C/hr