{"id":715,"date":"2020-04-27T14:41:38","date_gmt":"2020-04-27T14:41:38","guid":{"rendered":"http:\/\/iimcb.e-kei.pl\/corefacility\/?page_id=715"},"modified":"2026-01-20T17:50:04","modified_gmt":"2026-01-20T17:50:04","slug":"vp-itc","status":"publish","type":"page","link":"https:\/\/core-facility.iimcb.gov.pl\/vp-itc\/","title":{"rendered":"VP-ITC"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"715\" class=\"elementor elementor-715\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a67b69a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a67b69a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-90a3fa9\" data-id=\"90a3fa9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e859b12 elementor-widget elementor-widget-text-editor\" data-id=\"e859b12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #000000; font-size: 14pt;\"><strong>VP-ITC MicroCal\/Malvern Microcalorimetry<\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"><strong><span style=\"color: #000000;\">Room&nbsp; 612<\/span><br><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"><span style=\"color: #000000;\"><strong>Contact: <\/strong><\/span><a href=\"https:\/\/core-facility.iimcb.gov.pl\/roman-szczepanowski2\/\">Roman Szczepanowski<\/a><\/span><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"color: #000000; font-size: 14pt;\">Access to the instrument after short training <\/span><br><\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f4a0a24 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f4a0a24\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-30e7da3\" data-id=\"30e7da3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4f62e5b elementor-widget 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UnhideWhenUsed=\"true\" Name=\"Table List 7\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\" Name=\"Table List 8\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\" Name=\"Table 3D effects 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\" Name=\"Table 3D effects 2\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\" Name=\"Table 3D effects 3\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\" Name=\"Table Contemporary\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\" Name=\"Table Elegant\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" SemiHidden=\"true\" UnhideWhenUsed=\"true\" Name=\"Table Professional\"><\/w:LsdException><br \/>  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1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"69\" Name=\"Medium Grid 3 Accent 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"70\" Name=\"Dark List Accent 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"71\" Name=\"Colorful Shading Accent 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"72\" Name=\"Colorful List Accent 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"73\" Name=\"Colorful Grid Accent 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"60\" Name=\"Light Shading Accent 2\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"61\" Name=\"Light List Accent 2\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"62\" Name=\"Light Grid Accent 2\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"63\" Name=\"Medium Shading 1 Accent 2\"><\/w:LsdException><br \/>  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Name=\"List Table 2 Accent 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3 Accent 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4 Accent 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"50\" Name=\"List Table 5 Dark Accent 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"51\" Name=\"List Table 6 Colorful Accent 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"52\" Name=\"List Table 7 Colorful Accent 1\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"46\" Name=\"List Table 1 Light Accent 2\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"47\" Name=\"List Table 2 Accent 2\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3 Accent 2\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4 Accent 2\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"50\" Name=\"List Table 5 Dark Accent 2\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"51\" Name=\"List Table 6 Colorful Accent 2\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"52\" Name=\"List Table 7 Colorful Accent 2\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"46\" Name=\"List Table 1 Light Accent 3\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"47\" Name=\"List Table 2 Accent 3\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3 Accent 3\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4 Accent 3\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"50\" Name=\"List Table 5 Dark Accent 3\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"51\" Name=\"List Table 6 Colorful Accent 3\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"52\" Name=\"List Table 7 Colorful Accent 3\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"46\" Name=\"List Table 1 Light Accent 4\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"47\" Name=\"List Table 2 Accent 4\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3 Accent 4\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4 Accent 4\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"50\" Name=\"List Table 5 Dark Accent 4\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"51\" Name=\"List Table 6 Colorful Accent 4\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"52\" Name=\"List Table 7 Colorful Accent 4\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"46\" Name=\"List Table 1 Light Accent 5\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"47\" Name=\"List Table 2 Accent 5\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3 Accent 5\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4 Accent 5\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"50\" Name=\"List Table 5 Dark Accent 5\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"51\" Name=\"List Table 6 Colorful Accent 5\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"52\" Name=\"List Table 7 Colorful Accent 5\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"46\" Name=\"List Table 1 Light Accent 6\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"47\" Name=\"List Table 2 Accent 6\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"48\" Name=\"List Table 3 Accent 6\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"49\" Name=\"List Table 4 Accent 6\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"50\" Name=\"List Table 5 Dark Accent 6\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"51\" Name=\"List Table 6 Colorful Accent 6\"><\/w:LsdException><br \/>  <w:LsdException Locked=\"false\" Priority=\"52\" Name=\"List Table 7 Colorful Accent 6\"><\/w:LsdException><br \/> <\/w:LatentStyles><br \/><\/xml><![endif]--><!-- [if gte mso 10]><\/p>\n<style>\n \/* Style Definitions *\/<br \/> table.MsoNormalTable<br \/>\t{mso-style-name:\"Table Normal\";<br \/>\tmso-tstyle-rowband-size:0;<br \/>\tmso-tstyle-colband-size:0;<br \/>\tmso-style-noshow:yes;<br \/>\tmso-style-priority:99;<br \/>\tmso-style-parent:\"\";<br \/>\tmso-padding-alt:0cm 5.4pt 0cm 5.4pt;<br \/>\tmso-para-margin-top:0cm;<br \/>\tmso-para-margin-right:0cm;<br \/>\tmso-para-margin-bottom:8.0pt;<br \/>\tmso-para-margin-left:0cm;<br \/>\tline-height:107%;<br \/>\tmso-pagination:widow-orphan;<br \/>\tfont-size:11.0pt;<br \/>\tfont-family:\"Calibri\",sans-serif;<br \/>\tmso-ascii-font-family:Calibri;<br \/>\tmso-ascii-theme-font:minor-latin;<br \/>\tmso-hansi-font-family:Calibri;<br \/>\tmso-hansi-theme-font:minor-latin;<br \/>\tmso-bidi-font-family:\"Times New Roman\";<br \/>\tmso-bidi-theme-font:minor-bidi;}<br \/><\/style>\n<p><![endif]--><\/p><p style=\"text-align: justify;\"><span style=\"color: #000000; font-size: 12pt;\">Bio-Microcalorimetry enables the thermodynamic characterization of\u00a0 macromolecules like <span style=\"mso-spacerun: yes;\">\u00a0<\/span>proteins, nucleic acids, antibodies, lipids, oligosaccharides and many others, in solution.<\/span><\/p><p style=\"text-align: justify;\"><span style=\"color: #000000; font-size: 12pt;\">Its special example is <strong>Isothermal Titration Calorimetry (ITC)<\/strong>, which is dedicated to the study of molecular interactions. ITC is the only biophysical technique that can simultaneously determine all binding parameters: <strong>equilibrium constant (Ka), enthalpy (\u0394H), entropy (\u0394S) and stoichiometry <\/strong>of the reaction, in a single experiment. Interacting components does not require chemical tagging or immobilization.<\/span><\/p><p><span style=\"color: #000000; font-size: 12pt;\">Core Facility has MicroCal VP-ITC, a highly sensitive calorimeter that allows for analysis of dilute solutions of macromolecules (typically in the \u00b5molar range in case of proteins).<\/span><\/p><p><strong><span style=\"font-size: 14pt; font-family: 'Arial', sans-serif; color: #339966;\">Technical Specifications<\/span><\/strong><\/p><ul><li><span style=\"color: #000000; font-size: 12pt;\">ITC system can directly measure milimolar to nanomolar binding constants (Ka=10<sup>3<\/sup> x M<sup>-1<\/sup> &#8211; 10<sup>9<\/sup>x M<sup>-1<\/sup>).<\/span><\/li><li><span style=\"color: #000000; font-size: 12pt;\">The operating temperature range is of 5\u00b0C to 80\u00b0C.<\/span><\/li><li><span style=\"color: #000000; font-size: 12pt;\">Measuring cell material: Hastelloy<\/span><\/li><li><span style=\"color: #000000; font-size: 12pt;\">Experimental cell volume: 1,4 ml (safe loading require 2 ml of the sample)<\/span><\/li><li><span style=\"color: #000000; font-size: 12pt;\">Syringe volume: 280<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>\u00b5l (loading 500 \u00b5l total)<\/span><\/li><\/ul><p><span style=\"font-size: 14pt; color: #339966;\"><strong>Sample preparation requirements<\/strong><\/span><\/p><ul><li><span style=\"color: #000000; font-size: 12pt;\">Both, ligand and cell sample should be dissolved in the exactly same buffer .<\/span><\/li><li><span style=\"color: #000000; font-size: 12pt;\">If one molecule requires a small percentage of organic solvent for solubility, this same amount is required in<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>the<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>other<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>sample.<\/span><\/li><li><span style=\"color: #000000; font-size: 12pt;\">The starting concentration of ligand (in siringe) should be at least 10 times higher than the concentration of macromolecule.<\/span><\/li><li><span style=\"color: #000000; font-size: 12pt;\">The macromolecule concentration in the ITC cell is typically determined by the \u201cC parameter\u201d determined by: <\/span><span style=\"color: #000000; font-size: 12pt;\">C= N[M]T\/KD, \u00a0<span style=\"mso-spacerun: yes;\"> where <\/span><\/span><span style=\"color: #000000; font-size: 12pt;\">[M]T is the macromolecule concentration in the ITC cell, and N is the stoichiometry. To get a reasonable ITC binding isotherm, the optimal range is 5 &lt; C &lt; 500. <br \/><\/span><\/li><li><span style=\"color: #000000; font-size: 12pt;\">Viscous<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>additives<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>such<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>as<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>glycerol<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>should<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>be<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>kept<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>at<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>a<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>low<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>concentration <span style=\"mso-spacerun: yes;\">\u00a0<\/span>(less than 20%) for better mixing.<\/span><\/li><li><span style=\"color: #000000; font-size: 12pt;\">If<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>the<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>presence<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>of<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>reducing<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>agent<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>is<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>required<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>for<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>a<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>protein<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>stability,<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>use rather low concentration (1 mM) of TCEP or \u00df-mercaptoethanol<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>than DTT.<\/span><\/li><li><span style=\"color: #000000; font-size: 12pt;\">Buffers with a<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>large<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>enthalpy<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>of<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>ionization, like TRIS, are not recommended.<\/span><\/li><\/ul><p><strong><span style=\"font-size: 14pt; color: #339966;\">Reading <\/span><\/strong><\/p><p><strong><a href=\"http:\/\/iimcb.e-kei.pl\/corefacility\/wp-content\/uploads\/2020\/04\/vpitc_manual.pdf\"><span style=\"font-size: 12pt;\">VP-ITC MicroCalorimeter User\u2019s Manual<\/span><\/a><br \/><\/strong><\/p><div>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Isothermal titration calorimetry (ITC) thermogram for the titration of ligand into RNA fragment.<\/div><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fa5fa7c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fa5fa7c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a602448\" data-id=\"a602448\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-35a0594 elementor-widget elementor-widget-image\" data-id=\"35a0594\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"768\" height=\"1208\" src=\"https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2021\/04\/itc_thermogram-768x1208.png\" class=\"attachment-medium_large size-medium_large wp-image-1005\" alt=\"ITC thermogram\" srcset=\"https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2021\/04\/itc_thermogram-768x1208.png 768w, https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2021\/04\/itc_thermogram-381x600.png 381w, https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2021\/04\/itc_thermogram-651x1024.png 651w, https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2021\/04\/itc_thermogram-976x1536.png 976w, https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2021\/04\/itc_thermogram-1302x2048.png 1302w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-94ebce2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"94ebce2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7a04745\" data-id=\"7a04745\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9610623 elementor-widget elementor-widget-image\" data-id=\"9610623\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1200\" height=\"645\" src=\"https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2020\/04\/ITC_-1612x867.jpg\" class=\"attachment-large size-large wp-image-717\" alt=\"\" srcset=\"https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2020\/04\/ITC_-1612x867.jpg 1612w, https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2020\/04\/ITC_-600x323.jpg 600w, https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2020\/04\/ITC_-768x413.jpg 768w, https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2020\/04\/ITC_-1536x826.jpg 1536w, https:\/\/core-facility.iimcb.gov.pl\/wp-content\/uploads\/2020\/04\/ITC_.jpg 1919w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>VP-ITC MicroCal\/Malvern Microcalorimetry Room&nbsp; 612 Contact: Roman Szczepanowski Access to the instrument after short training Bio-Microcalorimetry enables the thermodynamic characterization of\u00a0 macromolecules like \u00a0proteins, nucleic acids, antibodies, lipids, oligosaccharides and many others, in solution. Its special example is Isothermal Titration Calorimetry (ITC), which is dedicated to the study of molecular interactions. ITC is the only [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-715","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/core-facility.iimcb.gov.pl\/wp-json\/wp\/v2\/pages\/715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/core-facility.iimcb.gov.pl\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/core-facility.iimcb.gov.pl\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/core-facility.iimcb.gov.pl\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/core-facility.iimcb.gov.pl\/wp-json\/wp\/v2\/comments?post=715"}],"version-history":[{"count":26,"href":"https:\/\/core-facility.iimcb.gov.pl\/wp-json\/wp\/v2\/pages\/715\/revisions"}],"predecessor-version":[{"id":2796,"href":"https:\/\/core-facility.iimcb.gov.pl\/wp-json\/wp\/v2\/pages\/715\/revisions\/2796"}],"wp:attachment":[{"href":"https:\/\/core-facility.iimcb.gov.pl\/wp-json\/wp\/v2\/media?parent=715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}